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The prefix 'mega' in scientific notation is denoted by the symbol 'M', which represents a factor of one million (10^6). This prefix is commonly used in various scientific fields, including physics, engineering, and healthcare, to indicate large quantities. For example, in ultrasound imaging, you might encounter frequency measurements in megahertz (MHz), which reflect millions of cycles per second.

In comparison, the other options represent different prefixes: the letter 'G' signifies 'giga,' which represents one billion (10^9), 'k' stands for 'kilo' meaning one thousand (10^3), and 'h' corresponds to 'hecto,' representing one hundred (10^2). Therefore, 'M' is the correct symbol for 'mega,' while the other options represent significantly different quantities.